Early-onset Alzheimer's disease steals the mind of a very smart woman in this moving and heartbreaking film. Julianne Moore plays Alice, a professor at Columbia University who leads a very organized and regimented life of lectures, dinner parties and runs in the park. Alice starts forgetting words here and there, and then proceeds to lose her place in lectures. When she loses her way during a routine jog and can't find her way home, she begins to realize that these aren't normal memory loss problems for a 50-year-old woman. At first, Alice thinks she has a brain tumor. But some memory tests suggest to her neurologist (Stephen Kunken) that something else could be causing her difficulties. After a series of brain scans, the conclusion is made: Alice has Alzheimer's. Moore gives us a deep, fully realized, multi-dimensional performance that never overdoes the sentiment or feels trite. Alice is a woman who prides herself on her encyclopedic knowledge for teaching, and exhibits nothing but grace as that knowledge is rapidly stripped away. Credit Moore for making every step of Alice's tribulations seem honest and credible. A great supporting cast includes Alec Baldwin, Kristen Stewart and Kate Bosworth.